So how the fuck can they do Wesker right, since obviously they're going for RE5 next?
Just look at all this nonsense, Jesus effin' Christ.
I'd say no matter what they're going for in RE5R, first thing they need to do is completely remove co-op and make Wesker more like Nicholai, but with a lot more added screentime and interaction in cut-scenes. There should be no direct fights with him as he and Nicholai are at their best when they're ruining your plans, always one step ahead and only periodically showing up here and there at crucial moments. If Wesker needs to go at some point by our hands one way or the other, it should be similar to how RE3 did it for Nicholai without direct gameplay and combat confrontation - Krauser-like mutation also not gonna cut it in any way shape or form, so fuck that too.
As fot the rest of the game.... oh, dear god. They need to literally move an effin' planet to save it. Absolutely everything related to gameplay and core design of original needs to be thrown into a volcano and pissed all over from the top as a finishing blow. Everything they did with this game is wrong. Africa setting - GTFO! How the game can even be called RE and be in survival horror genre if 90% of the whole game, you're under a blazing hot African sun and +50°!? WHAT? Fuck all that. This game was originally built from the ground up to be mindless and dumb co-op TPS with heavy reliance on action even more so than original RE4., there's no saving it without a complete re-design closer to RE2-3 and the best parts of RE4 (not the Island).
RE5 can be a devastating blow to RE IP all over again if they'll stick to almost everything that was in original, only changing things here and there like they did for RE4 (removing dumb shit, replacing it with far more interesting stuff), it won't fix anything, cuz it's rotten to the core no matter how you'll be dancing around it. RE4 still not perfect, but it's miles better than original game and much closer to what RE should be. This is where you need to use "completely destroy and create something new" approach and by need I mean you litteraly have no other choice with RE5, it can't be turned in to RE4 situation by only selectively removing dumb shit.
I don't like RE7 and RE8 that much (latter more than the former)... but even considering everything these game done right and completely wrong (or just not interesting whatsoever), they're still miles better than original RE5, Capcom! For the love of fuck don't fuck it up! I even can close my eyes if RE9 won't be that much better than 7 and 8, but ONLY IF I'll know that RE5 will be effin' amazing and completely devoid of everything original game was starting from design, heavy reliance on action and co-op and ending with setting, pure ridiculousness and sheer stupidity and absurdity of everything else.
Not only is your company's reputation is at stake here, but also people's reception and their attitude towards your company, their will and desire to support it and ultimately fund your future projects. Capcom, you seriously need to ask yourself a question - are you sure you can recover from another RE6 disaster and stay afloat thanks to Monster Hunter and SF? You can't effin' fix the core design of the game once it's already done with a patch and get people's strust and money back. Think about it a million times before doing anything while and if there's still time, there's no going back after the final decision is being made.