So, been playing a lot, go check with Vik for any new upgrades, get a tarot reading from Misty before heading to a nearby gang event for some cash, only to realize I couldn't use any of my weapons, or items; all character actions were blocked, and stamina and health unviewable.
I went through half-hour of autosave and tracked it down to a reproducible bug: head back to the Nomad camp after the Storm mission and talk to Panam, and the game will disable actions during the convo but won't re-enable afterwards. Reloading/restarting doesn't work, and neither does getting killed. Might be possible to fix with another event that properly disables/re-enables it, but probably best to avoid.
Edit: FUCK. Checking out the bug, I forgot to make a manual save after getting control back. Now all my autosaves are fucked with me unable to use weapons, and my last manual save is over an hour old. Not as bad as it could be, and I'll check if I can fix it, but fuck.
Edit2: Got control back. A cutscene that takes control from you should give it back. Failing that, a joytoy visit will work, if anyone else encounters this at some point.