I was reading last night's preview and I thought about how insane the possibilities are with this new aiming mechanic. For example, I shoot some random triad, not in a mission situation. I make sure he's across the street. As he inevitably comes running at me, I will do the half lock, aim for his lower leg and cause him to stumble and or fall.
With Euphoria we know that this is no longer an animation, and that once the leg has been hit the physics take over and anything can happen. If he stumbles and takes time to get up, you can only hope there will be a speeding vehicle, preferably something like a bus or 18 wheeler, but we'll take what we can get.
As for being on top of tall buildings, R* has said that you can cause deaths from up above. It would be fun to chase or be chased to a tall building and use the aiming mechanic to cause an awesome fall. If the guy is in the vicinity of the ledge, you can shoot either shoulder to swing his momentum enough to drop him. This will be a fun little minigame.
One thing I do hope makes it into GTA4 is something that I loved about Saint's Row. Being able to toss a grenade into a vehicle, actually shattering the glass and making it's way into the car. This made for alot of wow moments because once the grenade was in, the driver would panic and drive erratically ending in not only the driver's death, but a chain of events harming people around the explosion. I believe the way old GTA's did it was that the grenade just landed on the ground around the car, but I'm not positive.