Welp, I finally killed Yarnham the Queen. Beat her first time, though I'm starting to wonder if I'm just wildly overlevelled (~150). It's kind of hard not to be when going through the entire Chalice run and normal enemies are dropping 5000-10000 echos each. I never stopped to grind and rarely did I ever need to do the levels more than once (I usually would clear out a level first time, go back and cash in my echoes, then die repeatedly at the bosses). Even the headless beast I beat second time by mostly tanking him and playing mildly cautiously.
So, the hardest bosses in the Chalice run (in my experience) were the Loran Darkbeast, the Abhorrent Beast (level 5 Loran), the second time facing the fire dog (just because your HP is halved and he one shots you with most stuff), and the Chalice Rom fight (MASSIVE test of patience). The rest weren't too bad.
I still haven't bought the DLC, which leaves me in a tough spot; I'd like to get the Platinum (which I'm assuming you don't need the DLC for), but I unknowingly subjugated myself to a second run because I:
1) Missed Eileen COMPLETELY on my playthrough. I have no idea how I didn't meet her even once, but somehow I managed to. I swear I explored everywhere as thoroughly as I could, but totally missed her. As such, I never got her weapon/badge, so I'll have to get that on New Game plus
2) I ate all the 1/3 Umbilical Cords before chatting with the last boss, so I can't get the two normal endings anymore. So I'll need to do another run for that as well :/
I was thinking I was just going to clean all this up on a quick NG+ run, but I don't want to do the DLC on NG+ on my first time (since I've heard it's a little too rough on NG+).
So now do I
A) start up a new game and rush to the ending to clean up those two normal endings (I don't want to do the Chalice dungeons again, so I'm not going to get the Beast Claw, so I wouldn't be getting that All Weapons Trophy from that)
B) Do a wacky save scum...basically, save what I have now and put it on a USB stick (right before last boss on NG), then go to NG+, speed through and kill Eileen for her weapon then roll back to my pre-NG+ save and wait til the DLC goes on sale.
...but I guess I would still need to do another run to beat the game with the normal and bad endings. *sigh*
I really muffed this up. Hahahah