First, it was the Red Wedding episode in GoT; it was at that point, the most iconic moment in television for me, and I kept searching for another dopamine hit in movies and film. GoT was never able to replicate that moment.
Then, the Last of Us Part 2 story.
It's not a perfect game. There are moments that are forgettable, even poor. But the story...the way the writers manipulate you into feeling visceral hate, and then watching Ellie become the villain, while you wrestle with your own feelings about Abby; how Ellie has to with her own guilt of shunning Joel. It goes beyond the remit of video games, and it's no surprise that I don't think we've had anything come close to it in terms of raw emotional impact.